Efficient, Scalable Syntheses of Linker Molecules for Metal-Organic Frameworks

Knut T. Hylland; Sigurd Øien-Ødegaard; Karl Petter Lillerud; Mats Tilset

doi:10.1055/s-0034-1381039

Synlett, Table of Contents

Synlett 2015; 26(11): 1480-1485
DOI: 10.1055/s-0034-1381039

letter

Efficient, Scalable Syntheses of Linker Molecules for Metal-Organic Frameworks

Authors

Knut T. Hylland

Department of Chemistry, University of Oslo, P. O. Box 1033 Blindern, 0315 Oslo, Norway Email: mats.tilset@kjemi.uio.no
Sigurd Øien-Ødegaard

Department of Chemistry, University of Oslo, P. O. Box 1033 Blindern, 0315 Oslo, Norway Email: mats.tilset@kjemi.uio.no
Karl Petter Lillerud

Department of Chemistry, University of Oslo, P. O. Box 1033 Blindern, 0315 Oslo, Norway Email: mats.tilset@kjemi.uio.no
Mats Tilset*

Department of Chemistry, University of Oslo, P. O. Box 1033 Blindern, 0315 Oslo, Norway Email: mats.tilset@kjemi.uio.no

Abstract

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Dedicated to Professor K. Peter C. Vollhardt on the occasion of his 69^th birthday and 25 years of service to SYNLETT

Abstract

Efficient synthesis protocols for five linkers of immediate interest for use in metal-organic frameworks (MOFs) are presented. The importance of scalable, cost-effective, high-yield processes with simple purifications and few steps is emphasized. The protocols allow for the efficient synthesis of biphenyl-, terphenyl-, and quaterphenyl-based linkers. Four of the linkers have been structurally characterized.

Keywords

metal-organic frameworks - ligands - biaryls - coupling - materials science

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References

References and Notes
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36 Synthesis of Diethyl 2′,3′′-Dimethyl-[1,1′:4′,1′′:4′′,1′′′-quaterphenyl]-4,4′′′-dicarboxylate (2e) To a 100 mL Schlenk flask were added 3a (3.21 g, 7.39 mmol, 1.0 equiv), 2d (3.76 g, 19.4 mmol, 2.6 equiv), K₂CO₃ (6.15 g, 44.5 mmol, 6.0 equiv), Pd(OAc)₂ (0.039 g, 0.180 mmol, 0.0240 equiv), Ph₃P (0.195 g, 0.740 mmol, 0.100 equiv), and DMF (55 mL). The pale yellow suspension was flushed with argon for 30 min, before it was heated at 95 °C for 24 h under argon. The reaction mixture, which had turned black/dark brown, was cooled to r.t. and poured into a mixture of ice and H₂O (ca. 300 mL). The brown solid was filtered and washed with H₂O, then dried at r.t. for 3 h, before it was dissolved in CH₂Cl₂ (300 mL). The solution was washed with 3 M HCl (aq, 200 mL) and brine (200 mL) and dried with Na₂SO₄, before it was filtered through celite. The celite was washed with additional CH₂Cl₂ (10 × 30 mL). Removal of the solvent under reduced pressure yielded a pale brown solid which was recrystallized from MeCN. This gave 2e as a colorless solid. Yield 2.73 g, 5.71 mmol, 77%, mp (MeCN): 151–152 °C. ¹H NMR (600 MHz, CDCl₃): δ = 8.12 (d, J = 7.8 Hz, 4 H), 7.56 (d, J = 1.8 Hz, 2 H), 7.53 (dd, J^o = 7.8 Hz, J^m = 1.8 Hz, 2 H), 7.45 (d, J = 7.8 Hz, 4 H), 7.33 (d, J = 7.8 Hz, 2 H), 4.42 (q, J = 7.2 Hz, 4 H), 2.36 (s, 6 H), 1.43 (t, J = 7.2 Hz, 6 H). ¹³C NMR (150 MHz, CDCl₃): δ = 166.5 (C), 146.2 (C), 140.2 (C), 140.1 (C), 135.7 (C), 130.1 (CH), 129.4 (CH), 129.3 (CH), 129.2 (CH), 129.1 (C), 124.6 (CH), 61.0 (CH₂), 20.6 (CH₃), 14.4 (CH₃). IR (KBr): 1714.7, 1606.4, 1284.2, 1102.1, 776.9 cm^–1. MS (EI, CH₂Cl₂): m/z = 478 (100) [M]⁺, 433 (12) [M⁺ – OEt], 194 (6). HRMS (CH₂Cl₂): m/z calcd for C₃₂H₃₀O₄: 478.214410 (–3.4 ppm); found: 478.212763. Synthesis of 2′,3′′-Dimethyl-[1,1′:4′,1′′:4′′,1′′′-quaterphenyl]-4,4′′′-dicarboxylic Acid (1e) A suspension of 2e (2.08 g, 4.34 mmol, 1.0 equiv) and KOH (1.30 g, 23.2 mmol, 5.3 equiv) in a mixture of 1,4-dioxane (25 mL) and H₂O (30 mL) was heated at reflux for 18 h. After cooling to r.t., the solvent was removed under reduced pressure. H₂O (150 mL) was added to the resulting solid. The mixture was heated at reflux until the solid dissolved, and the solution was filtered while hot to remove insoluble impurities. Concentrated HCl (37%) was then added to the hot solution until pH = 1 with the formation of a colorless solid. After cooling to r.t., the solid was filtered and washed several times with H₂O, before it was air-dried overnight. The solid was then crushed to a powder, suspended in H₂O (200 mL) and stirred at r.t. for 1 h. Filtration, followed by washing with H₂O and drying at 100 °C for 24 h, gave 1e as colorless solid. Yield 1.57 g, 3.71 mmol, 85%; mp (H₂O): >310 °C. ¹H NMR (400 MHz, DMSO-d ₆): δ = 13.01 (br s, 2 H, CO₂H), 8.02 (d, J = 8.0 Hz, 4 H), 7.70 (d, J = 2.0 Hz, 2 H), 7.63 (dd, J^o = 8.0 Hz, J^m = 2.0 Hz, 2 H), 7.53 (d, J = 8.0 Hz, 4 H), 7.33 (d, J = 8.0 Hz, 2 H), 2.33 (s, 6 H, CH₃). ¹³C NMR (100 MHz, DMSO-d ₆): δ = 167.2 (C), 145.4 (C), 139.5 (C), 139.1 (C), 135.4 (C), 130.1 (CH), 129.4 (CH), 129.3 (CH), 129.2 (CH), 128.8 (C), 124.3 (CH), 20.3 (CH₃). IR (KBr): 2927.2, 1681.0, 1607.6, 1431.0, 1297.5, 1320.2 cm^–1. MS (EI, DMSO): m/z = 422 (100) [M]⁺, 378 (7) [M⁺ – CO₂]. HRMS (DMSO): m/z calcd for C₁₆H₁₄O₄: 422.151809 (2.8 ppm); found: 422.150624.
37 CCDC 1053020-1053023 contain the supplementary crystallographic data for 1a, 1b, 1d, and 1e. These data can be obtained free of charge from The Cambridge Crystallographic Data Centre via www.ccdc.cam.ac.uk/data_request/cif.
38 Allen FH, Kennard O, Watson DG, Brammer L, Orpen AG, Taylor R. J. Chem. Soc., Perkin Trans. 2 1987; S1

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